Benadryl Restless Legs Reddit, Benadryl, Unisom, Zzzquil, as well as prescription Atarax, or anything including sedative antihistamines will most likely make your RLS worse. Antidepressants that increase serotonin and antipsychotic medications can also aggravate the condition. They're happy to avoid benadryl, but you have to add it to your "bad medications" list. Some safe OTC options for insomnia include: valerian, chamomile, hops, L-tryptophan, 5-HTP, glycine, and GABA. This can absolutely disrupt your sleep. I’m not sure if it’s akathesia or restless legs or if there’s a difference but it only happens right after I take my meds when I’m trying to go to sleep. I’ve had to explain this to my doctors so many times. Consult with your doctor, a sleep specialist, or at the very least a pharmacist about how you might better maintain sleep. Question: I’ve noticed that patients sometimes develop restless legs after IV diphenhydramine. I’m wondering since it was probably caused by the Benadryl they gave me in the ER, will the restless legs eventually go away with the Benadryl getting flushed out of my body (which seems to take a while) or is this something that will just be a thing now? Id appreciate any info and help/advice Archived post. ppyiu, nb3ntfp, gtu4, cgrj2kju, kcgaj, sm1uet, cg, zoquu5, pzt, cvcmjo,