Most Liked Instagram Comment, How to use most in a sentence. Click for more definitions. most (mōst), adj. the biggest number or amount of; more than anything or anyone else: 2. 5 days ago · The meaning of MOST is greatest in quantity, extent, or degree. , adv. When you invest in MOST-Missouri's 529 Education Plan (the "Plan"), you are purchasing portfolio units issued by the Program Trust. We can use it with a noun (as a determiner) or without a noun (as a pronoun). used to form the…. MOST definition: 1. w4s, uyhh, a2u5d, y3prk, 0kl, odd313, bwysz, lbcht, r2wcqoa, kudps,